Idiosyncratic drug reaction is defined as which of the following?

Idiosyncratic drug reaction is defined as which of the following?

• A. A type of reaction that cannot be predicted and is not related to dose or known effects
• B. A reaction that is always dose-related
• C. A reaction that is always predictable
• D. A reaction that only occurs with antibiotics

Answer: (A)

Idiosyncratic drug reactions are uncommon, unpredictable responses that do not correlate with the dose of the drug or its known pharmacologic effects. This means they aren’t caused by simply higher exposure and can’t be anticipated from typical drug action data. These reactions often stem from individual factors such as genetic differences in metabolism or immune sensitivity, so they can occur unpredictably and at any time. They are not limited to antibiotics and can arise with many different drugs.

Idiosyncratic drug reactions are uncommon, unpredictable responses that do not correlate with the dose of the drug or its known pharmacologic effects. This means they aren’t caused by simply higher exposure and can’t be anticipated from typical drug action data. These reactions often stem from individual factors such as genetic differences in metabolism or immune sensitivity, so they can occur unpredictably and at any time. They are not limited to antibiotics and can arise with many different drugs.